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Pamer, Eric
One or more keywords matched the following properties of Pamer, Eric
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overview Humans and other mammals are colonized by complex populations of microbes that constitute the microbiota. Some commensal bacteria enhance immune defenses by inducing host expression of antimicrobial factors while others secrete antimicrobial molecules that inhibit pathogens. We study interactions between pathogenic and beneficial bacteria and their mammalian hosts. Our laboratory’s research focuses on a wide range of commensal bacteria that have been characterized at the genomic, proteomic and metabolomic level and we are using gnotobiotic mice to test assembled commensal consortia for their ability to enhance resistance against pathogenic bacteria. Using these platforms, we have identified multiple novel mechanisms of antimicrobial resistance that can be exploited to reduce the risk of infection by highly antibiotic-resistant pathogens. Our laboratory has worked closely with clinical groups to investigate the role of the microbiota in clinical outcomes. We have demonstrated that loss of microbiota diversity during allogeneic hematopoietic cell transplantation adversely impacts outcomes and have investigated the impact of microbiota composition on the risk of developing colitis during checkpoint blockade cancer immunotherapy.
One or more keywords matched the following items that are connected to Pamer, Eric
Item TypeName
Concept Bacterial Outer Membrane Proteins
Concept Bacterial Proteins
Concept Membrane Proteins
Concept Nerve Tissue Proteins
Concept Heat-Shock Proteins
Concept Hemolysin Proteins
Concept Proteins
Concept Monocyte Chemoattractant Proteins
Concept Intercellular Signaling Peptides and Proteins
Concept Proto-Oncogene Proteins B-raf
Concept WT1 Proteins
Concept Recombinant Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Pore Forming Cytotoxic Proteins
Concept Carrier Proteins
Concept Recombinant Fusion Proteins
Concept Adaptor Proteins, Vesicular Transport
Academic Article Early programming of T cell populations responding to bacterial infection.
Academic Article Rescue of CD8 T cell-mediated antimicrobial immunity with a nonspecific inflammatory stimulus.
Academic Article Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.
Academic Article Innate immune activation and CD4+ T cell priming during respiratory fungal infection.
Academic Article Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection.
Academic Article A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule.
Academic Article Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure.
Academic Article Microbiota-mediated inflammation and antimicrobial defense in the intestine.
Academic Article Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation.
Academic Article Expression and deletion analysis of the Trypanosoma brucei rhodesiense cysteine protease in Escherichia coli.
Academic Article MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses.
Academic Article Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
Academic Article CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen.
Academic Article TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus.
Academic Article T cell affinity maturation by selective expansion during infection.
Academic Article In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Academic Article Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies.
Academic Article CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.
Academic Article Control of T cell antigen reactivity via programmed TCR downregulation.
Academic Article In vitro stimulation with WT1 peptide-loaded Epstein-Barr virus-positive B cells elicits high frequencies of WT1 peptide-specific T cells with in vitro and in vivo tumoricidal activity.
Academic Article MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.
Academic Article Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells.
Academic Article Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Academic Article A nonamer peptide derived from Listeria monocytogenes metalloprotease is presented to cytolytic T lymphocytes.
Academic Article Selective expansion of the monocytic lineage directed by bacterial infection.
Academic Article Cell-mediated immunity: the role of bacterial protein secretion.
Academic Article Variable binding affinities of listeriolysin O peptides for the H-2Kd class I molecule.
Academic Article Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.
Academic Article Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection.
Academic Article Efficiency of MHC class I antigen processing: a quantitative analysis.
Academic Article Perforin-deficient CD8+ T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes.
Academic Article Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection.
Academic Article Intestinal and splenic T cell responses to enteric Listeria monocytogenes infection: distinct repertoires of responding CD8 T lymphocytes.
Academic Article Cutting edge: antigen-independent CD8 T cell proliferation.
Academic Article A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
Academic Article Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors.
Academic Article Monocyte-mediated defense against microbial pathogens.
Academic Article Coordinating innate immune cells to optimize microbial killing.
Academic Article Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection.
Academic Article The Listeria monocytogenes-secreted p60 protein is an N-end rule substrate in the cytosol of infected cells. Implications for major histocompatibility complex class I antigen processing of bacterial proteins.
Academic Article Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display.
Academic Article Robust recall and long-term memory T-cell responses induced by prime-boost regimens with heterologous live viral vectors expressing human immunodeficiency virus type 1 Gag and Env proteins.
Academic Article H2-M3-restricted memory T cells: persistence and activation without expansion.
Academic Article TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection.
Concept Pancreatitis-Associated Proteins
Grant H2-M3 RESTRICTED T CELL RESPONSES
Academic Article Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile.
Search Criteria
  • Antimicrobial
  • proteins